Department of Biochemistry

Overview

Department of Biochemistry was established in the year 1986 as an undergraduate department with an intake of 150 admissions per Academic year. The department was upgraded to Post Graduate department in the year 2005 with an intake of one PG per year. Later in the year 2009 it was upgraded with an additional PG M.D seat. In the same year department has been approved for Ph.D. admission. Till date, nine PG M.D and ten Ph.D. candidates have successfully completed their course. We are proud to say that for three consecutive years (2013, 2014 & 2015) candidates of this department have secured highest marks among pre-clinical subjects and were awarded Gold Medal. Ten Ph.D. candidates have been awarded Ph.D. degree from the department of Biochemistry till date.

The department is involved in teaching of nursing courses. The department is also involved in collaborative teaching of Post graduate students of various departments.

Department has well trained faculty with rich research experience in their respective thrust area. Each faculty is actively involved in research projects and completed projects are published in reputed indexed, peer reviewed Journals. Department of Biochemistry also encourages Undergraduate students who are interested in research activities to take STS ICMR projects and also our academy funded projects. The department has nine STS ICMR approved projects to its credit. Department has well-established Under Graduate and Post Graduate research laboratory. Post graduate research lab is well equipped with modern instruments and can accommodate 16 researchers to carry out their work simultaneously. The department has well equipped “Fluorosis Lab” situated in the research lab.

The department has 24x7 NABL accredited Clinical Biochemistry Diagnostic laboratory at CDLS, RLJH& RC. The laboratory provides a wide range of medical tests to provide quality services to the requirements of the patients, treating physicians and other users of the laboratory. Biochemistry laboratory is supporting to carry out various research activities of PG students and research scholars of different specialties. The lab is well equipped with instruments such as 5600, 5.1 FS & 250 Vitros Dry Chemistry Analyzer, BIORAD - D10 HPLC for HbA1C and also Electro Chemiluminescence for hormone assays. Routine Internal Quality Assessment (IQAS) is done twice daily to assess the quality of the lab. External Quality Assessment (EQAS, Bio Rad, USA) is done once a month and we are proud to say our results are on par with the International Standard.

Vision

“To be an excellent Biochemistry Department through Quality service, Academics & Research performance and to prepare students who are able to compete successfully in the Medical Profession”

Mission

“To promote innovative teaching in Graduate & Postgraduate programmes”
“To encourage a scientific collaboration environment”
“To translate research into practice”

Objectives

To achieve 100% pass percentage at both Under Graduate & Post Graduate level
To encourage Undergraduate and Postgraduate students to carry out research in their field of interest
To create interest for Undergraduate and Postgraduate students in the subject by introducing Evidence Based and Applied aspects of Biochemistry
To use research skills acquired from various academic activities, to design the experiments & to use appropriate statistical methods to analyze and interpret the data further to critically review the scientific literature
To provide training to the teaching staff & technicians by facilitating them to attend the training programme for ISO -15189 NABL Accreditation
To provide Quality Clinical Chemistry laboratory services 24×7 to the Clinicians of the hospital for the benefit of the patients

Programs

Best practice
Research day: one day in a week exclusively is given as Research Day for each staff. This policy was implemented to relieve the faculty from their routine activities enabling them to focus their concentration mainly on research projects which enhances the University publication quality.

Best practice 2
With respect to the Teaching, Learning and Evaluation the following competencies shall be incorporated for the M.B.B.S and Medical Laboratory Technology students.

Competencies with respect to I-MBBS:

Communication skills
Accurate pipetting of solutions
Request for appropriate investigations
Calculation of Mean and standard deviation
Interpretation of laboratory reports

Undergraduate Courses

Medical: MBBS
Nursing: B.Sc Nursing and PCB.Sc (N)

Trust Areas

Fluorosis Research & Mitigation
Oxidative stress markers, vitamins and minerals in Diabetes Mellitus and its complications
Novel Biomarkers, Oxidative stress and inflammatory markers in oral cancer

Publications

Year 2015: Total No. of Publications: 08

YEAR 2016: Total No. of Publications: 16

Year 2017: Total No. of Publications: 08

Year 2018: Total No. of Publications: 13

Year 2019: Total No. of Publications:15

Year 2020: Total No. of Publications: 10

YEAR 2021: Total No. of Publications: 14

Year 2022: Total No. of Publications: 10

Awards And Achivements

Sl. No.	Title of the Prize / Award	Faculty Name & Designation	Awarding Authority	Venue where awarded	Date/ year of Award
1.	Award for Best Poster.	Dr. Sumathi M.E	AMBICON-2012, National Conference.	Bhubaneswar, Odisha.	6th Dec to 12thDec 2012
2.	Thomas Edison Award- 2014	Munilakshmi.U	International Journal of Biochemistry-Photon	Online	February-2014
3.	Best Quality Manager Award -2018	Dr. Sumathi M.E	Academy of Medical Laboratory Auditors, Bengaluru	NIMHANS, Bengaluru	10th & 11th JULY 2018
4	Certified International Lead Assessor for Medical Laboratories across the world (FQI, AMLA, AER-SSC, QAI- ISO 15189; 2012 and ISO 22870; 2016).	Dr.K.N.Shashidhar	FQI, AMLA, AER-SSC, QAI- ISO 15189; 2012 and ISO 22870; 2016	Nepal	2019
5	National Academy of Medical Sciences Certificate	Dr.K.N.Shashidhar	National Academy of Medical Sciences	59thAnnual Conference of NAMS (NAMSCON 2019) which was held in AIIMS, Bhopal	11-10-2019 to 13-10-2019

Consultancy projects

Project title

Principal Investigator

Co-Investigators

Department

Details of Funding

A Randomized Double Blind parallel Group study to evaluate the Effect to Test Atta Plus metformin as Compared to Comparator Atta plus Metformin in Regulating Blood Glucose and Safety in Subjects with Type 2 Diabetes Mellitus

Dr.Shashidhar K.N

Dr. A.V. M. Kutty

Dr. Prabhakar .K

Biochemistry

General Medicine

Sponsor:ITC Atta Food Division

CEC Approval:No.SDUAHER/KLR/CEC/10/2017-18

Amount Sanctioned INR: 38,00,000.00

To evaluate safety of Mulmina Health Drink between two doses of COVID-19 Vaccine

Dr.Shashidhar K.N

Mrs. Sai Deepika. R

Mr. Bhuneshwar Yadav

Dr. Harish R

Dr. Sunil B

Dr. Raveesha A

Biochemistry

Community Medicine

Medicine

Sponsor: Juggat Pharma

CEC Approval: No.SDUAHER/KLR/CEC/49/2021-22

CTRI Reg. No: CTRI/2021/08/035747

Amount Sanctioned INR: 24,00000.00

Ongoing SDUAHER Funded Projects: 12

Sl.No.	Title	Principal Investigator	Co- Investigators
	The find association of Fluoride in Diabetes Type 2 and its Microvascular Complications: A Tertiary Care Rural Hospital Case Control Study	Dr.K.N.Shashidhar	Dr.Deena Mendez Dr. Munilakshmi.U Dr.A.V.M. Kutty Dr.Raveesha
1	Thiamine Status in Paediatric Sepsis - A Prospective Observational Study in a Tertiary Teaching Hospital	Dr. Sudha Reddy	Dr.Shashidhar.KN Dr. Prabhavathi. K
2	Antibody Status of SARS-CoV-2 Among Laboratory Confirmed COVID-19 Health Care Workers in a Tertiary care hospital: A Cross-Sectional Study	Dr. Arvind Natarajan	Dr.Shashidhar.KN
3	Vitamin A and Zinc-Enriched Nutrient Supplementation for Recovery Enhancement in patients with Tuberculosis (VZ-ENSURE): A Quasi Experimental Study	Dr. Wasim	Dr. Prasanna Kamath Dr. Prabhavathi. K
4	Efficacy of therapeutic aquatics over therapeutic exercise on balance & physical performance on diabetic neuropathy subjects	Ms. Sarulatha H	Dr. Prabhavathi. K
5	Quantitative assessment of interleukin-6 levels in benign, premalignant and malignant lesions of oral cavity	Dr. Azeem Mohiyuddin	Dr. Susanna TY
6	Does Vitamin D3 supplementation improve the Depression scores among rural adolescents? A randomized control trial	Dr. Pradeep	Dr. Susanna TY
7	Serum Lactate and Procalcitonin- Its Role in Predicting Mortality of Trauma	Dr. Sagar	Dr. Prabhu Dr. Arun HS Dr. Sai Ganesh Dr. Harish. R
8	Comparison of nutritional approaches of Ayurveda and modern nutrition with the biochemical parameters of young women with polycystic ovarian syndrome	Dr. Anees Fathima	Dr. Harish. R
9	Prevalence of anaemia in adolescents attending Government run schools around Kolar	Mr. Ravishankar	Dr. Harish. R
10	Herpes simplex virus Encephalitis detection by PCR and Serology in RL Jalappa Hospital, constituent of Sri Devaraj Urs Medical College, a unit of SDUAHER, Kolar	Dr. Namitha	Dr. Munilakshmi. U
11	Enriched Nutrition Supplementation for recovery Enhancement in patients with Tuberculosis (ENSURE): A quasi experimental study	Dr. Wasim Anjum	Dr.Prasanna Kamath Dr. Prabhavathi. K
12	Quantitative assessment of Interleukin in patient with Oral squamous cell carcinoma	Dr. Susanna. T.Y	Dr.Azeem Mohiyuddin

On going Faculty Projects: 04

Project Title	Principal Investigator	Co- Investigators
Assessment of Knowledge and Attitude about Oral Cancer among Outpatient Population in a Tertiary care Rural Hospital.	Dr. Susanna TY	Dr.Sagayaraj.A Dr.Anirudh Mr.Ravishankar
LDH and Ferritin- which is a better biomarker for progression from mild to severe illness in COVID 19 patients	Dr. Deena Mendez	Dr. Mamatha Kunder Dr. Munilakshmi. U
“Assessment of serum concentrations of Magnesium and calcium in mild and severe cases of COVID 19: Could they be severity markers for COVID 19?”	Dr. Mamatha Kunder	Dr. Deena Mendez Dr. Munilakshmi. U
Is SARS COV 2 infection concomitant with Renal parameters among Laboratory confirmed cases? A rural Hospital study	Dr. Munilakshmi. U	Dr. Bindu Madhavi, Dr. Deena Mendez Dr. Mamatha Kunder Dr. Prabhavathi. K

MD/MS Dissertations / Ph.D. Thesis

Completed PhD Thesis Projects under Faculty of Medicine: 10
Project Title	Name of the Supervisor	Name of the Scholar
Studies on Proteases of Pathogenic bacteria with special emphasis on elastase and natural anti elastase	Dr. AVM Kutty	Dr. Deena Mendez
Studies on serum elastase and elastase inhibitor levels in infectious and non-infectious diseases	Dr. AVM Kutty	Dr. Mamatha Kunder
A study on evaluation of Oxidative Stress with special emphasis to Xanthine oxidase activity, Antioxidants and plasma human Neutrophil Elastase	Dr. Dayanand CD	Dr. Vanishree B
Biomarkers and Oxidative Stress Parameters in Type 2 Diabetes Mellitus and Acute Kidney Injury	Dr. Shashidhar K N	Dr. Munilakshmi U
A correlative study of advanced biomarker: Kalistatin with conventional and oxidative markers in cirrhosis of Liver	Dr. Shashidhar K N	Dr. Krishna Sumanth
Study on evaluation of oxidative stress index, plasma placental proteins and their implication on vascular endothelial dysfunction in Preeclampsia	Dr. Dayanand CD	Dr. Ranjitha G
Circulating Angiogenic, oxidative stress markers and their association with endothelial function in normal pregnant and Preeclamptic women	Dr. Dayanand CD	Dr. Rajiv gandham
Estimation of Fluoride and Sirtuin1 in Patents with Diabetic Nephropathy in Kolar, Karnataka, India	Dr. Shashidhar K N	Dr. Sai Deepika
Association of Vitamin D binding protein in Diabetic Nephropathy: A cross sectional analytical study	Dr. Shashidhar K N	Dr. Bhuneshwar Yadav
Spexin as a novel biomarker and its relation with cardiometabolic parameters in metabolic syndrome	Dr. Dayanand CD	Dr. Tejaswi gowdu

Ongoing Dissertation projects: Co-guided by teaching faculty: 11

Sl No	Title of the research project	Principal investigator	Co-investigator	Departments
1	Role of Serum and aqueous humor magnesium levels as a marker in assessment of Diabetic Retinopathy in type 2 Diabetic and Non- Diabetic Patients	Dr. Aastha Garg	Dr. KN. Shashidhar	Opthalmology
2	Thiamine Status in Paediatric Sepsis - A Prospective Observational Study in a Tertiary Teaching Hospital	Dr. Sudha Reddy	Dr.Shashidhar.KN Dr. Prabhavathi. K	Paediatric Biochemistry
3	Prospective study on the association between cord blood vitamin D levels and early onset neonatal sepsis	Dr.Rajitha Reddy	Dr. Sudha Reddy Dr. Prabhavathi. K	Paediatric Biochemistry
4	An analysis of cericovaginal β-HCG and Prolactin levels as a predictive biomarker of preterm birth in symptomatic women: A prospective cohort study”	Dr. Akshitha Sai Ragam	Dr.Shashidhar KN	OBG Biochemistry
5	Co-guide for project titled “Serum CA125 level in normotensive and pre-eclamptic pregnancies in a tertiary care hospital”	Dr. Sahithya. S	Dr.Shashidhar KN	OBG Biochemistry
6	Phosphorylated Insulin like growth factor binding protein-1 as predictor of successful labor induction in full term pregnancy- A cross sectional study	Dr. Kolakotla Ajitha	Dr.Shashidhar KN	OBG Biochemistry
7	Urine protein to creatinine ratio for evaluation of preeclampsia and its maternal and fetal outcome: A Cross Sectional Study	Dr. Ashwini Kashi	Dr.Shashidhar KN	OBG Biochemistry
8	Association of elevated serum ferritin levels in pregnancy with gestational diabetes	Dr. Lakshmi	Dr.Shashidhar KN	OBG Biochemistry
9	The role of HbA1c as an early predictor of gestational diabetes mellitus in early pregnancy- A prospective study	Dr. Somavarapu Divya	Dr.Shashidhar KN	OBG Biochemistry
10	Clinical and laboratory profile in paediatric patients with bicytopenia or pancytopenia in a tertiary care centre in kolar- A cross sectional study	Dr.Ram Swaroop Reddy	Dr.Shashidhar KN	Paediatrics Biochemistry
11	Docosa Hexanoic acid supplementation in preterm neonates admitted in NICU and its effect on inflammatory markers at day 10- An open labelled Randomized Controlled Trial	Dr.MaramReddy Sai Teja	Dr.Shashidhar KN	Paediatrics Biochemistry